Victoria Orphan is a geobiologist whose research sheds new light on microbial communities in extreme environments and their impact on the cycling of nutrients and energy through the oceans. Much of her work focuses on microorganisms living in deep-sea beds that sequester large quantities of methane released from seeps in the ocean floor. Because these microbes cannot easily be cultured (or grown) in the laboratory, Orphan skillfully combines techniques from molecular biology and mass spectrometry into novel methods that enable the capture and analysis of the activities of individual microbial cells, as well as the relationships among different microbes, in their natural environments.